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We focus on the development and manufacture of microbial derived biopharmaceuticals, such as proteins, plasmid DNA, antibody fragments and protein scaffolds.

In state-of-the-art GMP facilities we manufacture products for clinical trials and market supply. Boehringer-Gasse A Vienna T.

Also in , we received the Customer Value Award for providing our international clients with the highest quality customer manufacturing.

Value through Innovation. Products are highly purified in modern recovery and purification units. Columns up to 1. Explosion-proof areas allow steps requiring the use of organic solvents or large scale high performance liquid chromatography.

Located on the campus of the University of Veterinary Medicine Vienna and having its roots in the Institute of Bacteriology, Mycology and Hygiene, a university institute which is internationally recognised for its research on mycoplasmas, Mycosafe is well-positioned to become a mycoplasma testing service center and developer of new mycoplasma testing assays of the future.

Since December , Mycosafe is operating under the new name Mycosafe Diagnostics GmbH and is today considered as a leading contract service and research organisation which plays an important role in the success of its clients in research and biopharmaceutical production by assuring the mycoplasma biosafety of cell banks, in-process samples, lot-release samples and raw materials.

Mycosafe also offers PhEur and US FDA compliant validation studies to qualify each mycoplasma testing assay for the respective product to be tested.

In addition, Mycosafe offers its expertise in mycoplasma species identification and strain characterisation using molecular techniques, and also provides consultancy and training services in the area of mycoplasmology.

In cooperation with academic and industrial partners, Mycosafe is developing and validating new innovative DNA-based testing systems for the detection and identification of mycoplasmas.

Both of these substances are approved as human drugs and are commonly used in hospitals. The drug is easy to use and the therapeutic dose has no significant side effects.

To the present day 16 countries have participated in the UACI research with more than scientists in 46 universities and research institutes.

The results of UACI research are regularly presented on international congresses and published in scientific magazines. Reading about that, one wonders if this discovery is suppressed because it is against some pharmaceutical companies' interests.

Our products target segments characterised by both unmet medical need and interesting revenue potential. This encompasses developmental skills, regulatory procedures and the synthesis of complex APIs and forms the key to a range of longterm competitive advantages.

The majority of our revenues are already generated through product sales. We consciously avoid broad-based and cost-intensive exploratory research.

Extensive in-house skills and resources are supplemented by numerous top-level scientific co-operations with contract research organisations, institutes and universities.

Profitable contract manufacturing orders, API synthesis and imaging diagnostic sales all contribute to steady revenue flows.

Additional potential lies in pipeline developments of new drugs for attractive segments of the pharmaceutical market. This in turn allows us to offer partners a wide range of services in the fields of contract synthesis and manufacturing.

We use our experience and knowledge to help clients to set up a mycotoxin control system and to manage the risk.

Romer Labs Diagnostic GmbH www. However, the purity of mycotoxin standards is often uncertain. Founded in the year , Biopure has developed world-leadership in the production of highly purified mycotoxin calibrants.

Today thousands of labs in all continents benefit from the liquid and solid calibrants supplied from Biopure. Because of new regulations, the testing of mycotoxins has become very important also for remote places, where no Labs can be established.

Vitateq was the first to discover that afamin, a human serum transport protein for vitamin E, is a major player in the development of reproductive tract tumors, infertility and neurodegenerative diseases.

Presently, there are no comparable products available on the market. Afamin exerts neuroprotective properties in neuronal cell culture models.

These results indicate a high potential for diagnostic and therapeutic applications of afamin not only in the fields of fertility and cancer, but also neuroprotection.

Vitateq has established an ELISA kit for quantifying afamin in human serum as a novel diagnostic tool for early, improved and more specific detection of cancers occurring in human reproductive tissues.

This ELISA kit is fully developed and has already been tested successfully in several human patient groups. Vitateq Biotechnology is a spin-off company from the Medical University of Innsbruck with international management.

Our product development is protected by several international patents. Our new diagnostic test will be based on a variety of significant and biologically relevant biomarkers.

Biochemistry Core competence of the company is to study changes of gene expression and function in human tissues during cancer development and ageing, with the intention to identify and validate new targets for early diagnosis of tumour-, age- and environmentinduced diseases.

The products are currently in preclinical trials. At present, cervical cancer screening is the largest existing screening market in oncology.

Worldwide, there are Human papilloma virus HPV induced cervical cancer is the most common cancer beneath breast cancer in women and, if detected early, cervical cancer is a fully preventable disease!

Partnerships Amynon Biotech GmbH follows an efficient strategy to protect intellectual property and has filed several patents.

The rights for production and distribution are licensed to partners from the pharmaceutical industry.

As a science-based and market oriented company Amynon is permanently interested in international cooperations with diagnostic and pharmaceutical companies to further develop and commercialize Amynon's products.

Make it visible - HPV-E7 oncoprotein detection in cervical smear. Its objective is to develop novel and innovative drugs for the treatment of diseases with a high degree of unmet medical needs.

Presently no drug is available to treat this life-threatening condition that is caused by a variety of diseases such as sepsis and pneumonias due to viral infections e.

ARDS may be the key complication in the context of the feared pandemic outbreak of a new influenza virus. A second project of Apeiron relates to the biologic role of Cbl-b, a key check-point molecule of the immune system.

The enzyme Cbl-b has been recognized as critical negative regulator of autoimmunity. Modulation of Cbl-b activity may enable effective vaccination strategies against weakly immunogenic antigens such as cancer, malaria, HIV-infection, or alternatively may lead to novel therapies for autoimmune diseases.

In a strategic partnership Apeiron identifies and profiles substances that interfere with Cbl-b activity. In a third project, Apeiron in a strategic alliance identifies compounds that modulate the biologic action of DREAM, a key molecule for the natural pain regulation by controlling the expression of an endogenous opioid.

Such compounds are expected to be powerful analgesics, based on the induction of the production of an endogenous opioid. Most of them have trusted CIS repeatedly with various kind of projects, from early development to submission for Marketing Authorisation.

CIS offers consulting and project management services, starting from the switch preclinical-to clinical development up to submission for marketing authorisation.

CIS has a broad experience in conducting audits in all major areas of clinical research. CIS prepares companies for inspections by health authorities.

The EUCODIS proprietary approach extends these natural limitations to recombination of highly diverged sequences and thus creates proteins with novel properties coded by the recombined gene sequence.

In addition to these collaborative service agreements, internal projects are focussed on biopharmaceuticals anti-inflammation and bone metabolism and two important enzyme classes.

Iterative stimulation of a human B-cell line allows the generation of specific, human antibodies or novel biopharmaceuticals. EUCODIS has a strong international network of leading experts for its individual projects which ensure optimal project design and performance of research and collaborative projects.

Major research collaborations with the Necker Faculty of Medicine and leading institutes in Europe linked via a major grant from EU focussing on human antibodies are in place.

Concurrently with the foundation of the U. The company aims to become a leader in the development and commercialisation of pharmaceuticals targeting fundamental mechanisms of inflammationbased tissue injury.

Inflammation-based tissue injury is well known as a major component in the pathogenesis of important diseases, such as myocardial infarction, septic and hemorrhagic shock, graft rejection or rheumatoid arthritis.

In parallel, research programs for additional indications for FX06 will be conducted and suitable indications for clinical development will be identified, with an emphasis on septic shock.

New peptides already identified will be analysed with respect to their usefulness for autoimmune diseases. In parallel, partnering discussions with a pharmaceutical partner for performance of phase III trials and commercialization will be started.

Phase IIa trials for additional indications for FX06 will be initiated in FIBREX Medical currently concentrates its efforts on the preclinical and clinical development of the products currently in its pipeline.

However, in-licensing of product candidates late preclinical or early clinical with a strategic fit will actively be pursued to complement the pipeline.

High quality PTR-MS instruments for satisfied customers from industry, university and private research have been employed in the food and fermentation control industries as well as for process and environmental monitoring.

The very low detection limit for volatile organic compounds VOCs , realtime measurements due to fast response times, and continuous monitoring capabilities are the major advantages of our innovative PTR-MS system.

This leads to our unique low detection threshold for trace compounds in the range of a few pptv. Compared to ordinary gas chromotography, our PTR-MS system provides the possibility of online and real-time measurement, because the instrument's response time is less than ms.

The company is also dedicated to providing top-level clinical research on a broader range of illnesses throughout all stages of therapy development.

JSW-Research uses modern molecular biology techniques and has also designed a variety of disease relevant cell and animal models for characterizing drug effects.

Interlacing modular systems facilitate step-by-step analysis of candidate substances from basic in vitro to complex in vivo assays, complemented by a full range of histological, biochemical and behavioral evaluation methods.

JSW-Research generates high quality research on two levels: First the company performs highly standardised contract research for the pharmaceutical industry and for well renown institutions like Harvard University, Mayo Clincs and the University of Tel Aviv.

Academia represents a significant proportion of the customers, since the Austrian enterprise is one of the technology leaders regarding preclinical and clinical research.

In a second branch JSW-Research performs proprietary drug development programs. The Austrian contract research and drug development company JSW-Research has specialised on the performance of experimental and clinical studies in the field of neurodegenerative diseases.

Windisch, CEO of JSW-Research: For the identification and evaluation of compounds we apply a broad spectrum of biochemical, cell biological and molecular biological methods.

Furthermore we are specialists in neuroscience and behavior and work with various animal models including transgenic mice.

Windisch founded the company in and gained profound knowledge during a 20 year career in drug research.

The clinical department of JSWResearch offers services in all clinical phases and indications.

Innovative research projects with high development and marketing chances are financed and managed by the Kompetenzzentrum Medizin Tirol KMT.

The main areas of research are implant technology, bioanalytics, cell therapy and nano- bio technology. With regard to project management, KMT has specialist experience and expertise in project planning, together with developing and managing project proposals, particularly in the area of life sciences.

As part of the contribution to the European research agenda, KMT is extending its customer services and promoting development of the Life Science Cluster Tirol at an international level.

KMT, as a center of excellence, has well established contacts with key stakeholders industry, academic, public authorities in life sciences in the region and beyond.

The first results from research and development activities of some KMT projects have already been successfully introduced onto the market.

The Tyrol region in Austria is particularly strong in the areas of cell therapy, immunology and bioanalytics. KMT manages large research and co-operative programmes on a national and international level.

Since its foundation in the year , Lambda GmbH has responded to the challenges in this field and now specializes in a wide range of molecular biological methods of detection.

The innovative biotechnology company with its roots in Freistadt, Austria, develops and produces biochips as ready to use kits for applications in research and routine diagnostics.

DNA analysis and customer research work are carried out by experienced specialists in Lambda's own laboratories.

Through its close collaboration with associates in industry and research, Lambda assures the practicality and reliability of its solutions.

Thus, the company which is owned by the Greiner Bio-One GmbH, develops biochips for the medical diagnostics. Products consist of complete test systems with all the necessary buffers and solutions.

The on-chip quality-control system, for which Lambda has already applied for a patent, guarantees perfect monitoring of every stage of analysis and production and therefore virtually excludes false negative and false positive results.

An IVD-compatible microarray scanner together with an integrated analysis software permit the fully automatic high-throughput detection and analysis of up to four biochips at once.

The Lambda-products are distributed worldwide by Greiner Bio-One. Since its foundation in , more than doctors as well as decision makers of public health authorities and members of ethics committees throughout Europe, Middle East and Africa have completed their postgraduate education in the area of clinical research at the VSCR.

The VSCR acts as a mediating institution between all interested parties including academia, industry, the public sector and society. As a networking centre, the VSCR promotes an international interdisciplinary exchange in the biotechnological research field and cooperates trustfully with its partner-universities to guarantee that the state-of-the-art education is based on academically recognized knowledge and.

This cooperation is the foundation of all educational activities undertaken by the VSCR. Rechenbeispiel siehe Seite 8.

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